Understanding Illness Trajectories and Developing Novel Therapies for Individuals With Psychosis

The role of schemas in the experience of distress, burden, and wellbeing in parents and siblings of people with serious mental health difficulties

A Jayasinghe, K Filia, AL Wrobel, G Karambelas, LK Byrne, G Melvin, C Gao, T Garvin, A Watson, M Hasty, C Macneil, L Berk, M Berk, S Cotton

2025-06-01

Background: Caregivers of people with serious mental health difficulties (SMHD), such as schizophrenia or bipolar disorder, face v..

Assessing Suicidal Ideation in Young People With Depression: Factor Structure of the Suicidal Ideation Questionnaire

CI Moller, PB Badcock, SE Hetrick, S Rice, M Berk, OM Dean, AM Chanen, C Gao, CG Davey, SM Cotton

2025-03-01

Evaluating suicidal ideation in young people seeking mental health treatment is an important component of clinical assessment and ..

Multiscale Heterogeneity of White Matter Morphometry in Psychiatric Disorders

A Segal, RE Smith, S Chopra, S Oldham, L Parkes, K Aquino, SM Kia, T Wolfers, B Franke, M Hoogman, CF Beckmann, LT Westlye, OA Andreassen, A Zalesky, BJ Harrison, CG Davey, C Soriano-Mas, N Cardoner, J Tiego, M Yücel

2025-01-01

Background: Interindividual variability in the neurobiological and clinical characteristics of mental illnesses are often overlook..

Multiscale Characterisation of Neural Abnormalities in Psychiatric Disorders

Ashlea Segal, Robert E Smith, Stuart Oldham, Sidhant Chopra, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian Beckmann, Lars Westlye, Ole Andreassen, Andrew Zalesky, Ben J Harrison, Christopher G Davey, Carles Soriano-Mas, Narcis Cardoner, Jeggan Tiego, Murat Yucel

2024-05-15

The Influence of Personality Disorder Symptoms on Treatment Outcomes in Bipolar Disorder: A Secondary Analysis of a Randomised Controlled Trial

Alessandra Sarmiento, Olivia M Dean, Bianca E Kavanagh, Mohammadreza Mohebbi, Michael Berk, Seetal Dodd, Sue M Cotton, Gin S Malhi, Chee H Ng, Alyna Turner

2024-04-01

Objectives: Many people who are diagnosed with bipolar disorder also have comorbid personality disorder. Few studies have explored..

Distress, burden, and wellbeing in siblings of people with mental illness: a mixed studies systematic review and meta-analysis

A Jayasinghe, A Wrobel, K Filia, LK Byrne, G Melvin, S Murrihy, C Moller, L Berk, M Berk, S Cotton

2023-11-25

Background Family members of people with mental illness (MI) may experience a host of psychological adversities such as increased ..

Understanding the complexity, patterns, and correlates of alcohol and other substance use among young people seeking help for mental ill-health

CX Gao, KM Filia, G Bedi, JM Menssink, E Brown, DJ Rickwood, AG Parker, SE Hetrick, H Herrman, I Hickie, N Telford, PD McGorry, SM Cotton

2023-10-01

Purpose: Use of alcohol and other substances is a multifaceted issue impacting young people across multiple life domains. This pap..

Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F Beckmann, Lars T Westlye, Ole A Andreassen, Andrew Zalesky, Ben J Harrison, Christopher G Davey, Carles Soriano-Mas, Narcis Cardoner, Jeggan Tiego, Murat Yucel, Leah Braganza, Chao Suo, Michael Berk

2023-09-01

The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case–control ..

Predictors of suicidal ideation severity among treatment-seeking young people with major depressive disorder: The role of state and trait anxiety

CI Moller, PB Badcock, SE Hetrick, S Rice, M Berk, K Witt, AM Chanen, OM Dean, C Gao, SM Cotton, CG Davey

2023-08-01

Objective: Depression and suicidal ideation are closely intertwined. Yet, among young people with depression, the specific factors..

Childhood trauma relates to worse memory functioning in bipolar disorder

TJ Ehrlich, H Kim, KA Ryan, SA Langenecker, ER Duval, AK Yocum, C Diaz-Byrd, AL Wrobel, OM Dean, SM Cotton, M Berk, MG McInnis, DF Marshall

2023-07-15

Background: Childhood trauma is commonly experienced by individuals diagnosed with bipolar disorder (BP). In BP, childhood trauma ..

Personality traits as mediators of the relationship between childhood trauma and depression severity in bipolar disorder: A structural equation model

AL Wrobel, SE Russell, A Jayasinghe, BE Kavanagh, M Lotfaliany, A Turner, OM Dean, SM Cotton, C Diaz-Byrd, AK Yocum, ER Duval, TJ Ehrlich, DF Marshall, M Berk, MG McInnis

2023-07-01

Background: Childhood trauma is negatively associated with depression severity in bipolar disorder; however, the underlying mechan..

Accelerating youth mental health services research

SM Cotton, KM Filia, MP Hamilton, CX Gao, JM Menssink, N Telford, P McGorry, D Rickwood

2023-06-01

Objective: We describe a research program to advance youth mental health service research in Australia, addressing two core knowle..

Characteristics and clinical needs of young tertiary students attending a specialist mood disorders clinic

KM O'Gorman, L Schmaal, A Ratheesh, G Habib, O Tokatlidis, J Jackson-Simpson, SM Cotton, SM Rice

2023-06-01

Objective: To investigate the clinical characteristics of tertiary students and non-students attending a specialist clinic for sev..

Inequalities in Access to Mental Health Treatment by Australian Youths During the COVID-19 Pandemic

CX Gao, LP McDonald, MP Hamilton, K Simons, JM Menssink, K Filia, D Rickwood, S Rice, I Hickie, PD McGorry, SM Cotton

2023-06-01

OBJECTIVE: The authors aimed to evaluate changes in use of government-subsidized primary mental health services, through the Medic..

Psychological distress in siblings of people with mental illness: A systematic review and meta-analysis

A Jayasinghe, A Wrobel, K Filia, LK Byrne, G Melvin, L Berk, M Berk, S Cotton

2023-05-01

Objective: The objective of this study was to characterise the prevalence and/or severity of psychological distress (namely, depre..

Prevalence and Correlates of Tobacco Use in Young People Presenting to Australian Primary Mental Health Services

Sue M Cotton, Sonia Sharmin, Caroline X Gao, Ellie Brown, Jana M Menssink, Debra Rickwood, Gillinder Bedi, Ian Hickie, Sarah E Hetrick, Alexandra G Parker, Helen Herrman, Nic Telford, Patrick D McGorry, Kate M Filia

2023-03-22

Introduction: In Australian youth primary mental health settings it is unclear as to the rates and correlates of tobacco use at se..

Childhood trauma and depressive symptoms in bipolar disorder: A network analysis

AL Wrobel, SM Cotton, A Jayasinghe, C Diaz-Byrd, AK Yocum, A Turner, OM Dean, SE Russell, ER Duval, TJ Ehrlich, DF Marshall, M Berk, MG McInnis

2023-03-01

Background: Childhood trauma is related to an increased number of depressive episodes and more severe depressive symptoms in bipol..

Heterogeneity of quality of life in the later stages of first-episode psychosis recovery

EL Clarke, K Allott, JFI Anderson, CX Gao, KM Filia, E Killackey, SM Cotton

2023-03-01

Purpose: First-episode psychosis (FEP) is characterised by wide heterogeneity in terms of symptom presentation and illness course...

A systematic review and meta-analysis of global and social functioning among people at risk of bipolar disorder

M Watson, K Filia, A Stevens, S Cotton, B Nelson, A Ratheesh

2023-01-15

Background: Functional status could predict development of bipolar disorder (BD) or have clinical significance. The relationship b..

A systematic review comparing caregiver burden and psychological functioning in caregivers of individuals with schizophrenia spectrum disorders and bipolar disorders

GJ Karambelas, K Filia, LK Byrne, KA Allott, A Jayasinghe, SM Cotton

2022-12-01

Background: Informal primary caregivers provide crucial supports to loved ones experiencing serious mental illnesses with profound..

A comparison of experiences of care and expressed emotion among caregivers of young people with first-episode psychosis or borderline personality disorder features

Sue M Cotton, Jennifer K Betts, Dina Eleftheriadis, Kate Filia, Mirra Seigerman, Victoria K Rayner, Ben McKechnie, Carol Anne Hulbert, Louise McCutcheon, Martina Jovev, Sarah Bendall, Emma Burke, Catharine McNab, Sumudu Mallawaarachchi, Mario Alvarez-Jimenez, Andrew M Chanen, John FM Gleeson

2022-09-01

Objective: Caregivers of individuals with severe mental illness often experience significant negative experiences of care, which c..

A protocol for the first episode psychosis outcome study (FEPOS): ≥15 year follow-up after treatment at the Early Psychosis Prevention and Intervention Centre, Melbourne, Australia

S Cotton, K Filia, A Watson, AJ Mackinnon, L Hides, JFM Gleeson, M Berk, P Conus, M Lambert, B Schimmelmann, H Herrman, V Rayner, A Ratheesh, PD McGorry

2022-07-01

Background: Specialist early intervention (SEI) service models are designed to treat symptoms, promote social and vocational recov..

Attachment insecurity partially mediates the relationship between childhood trauma and depression severity in bipolar disorder

AL Wrobel, SE Russell, A Jayasinghe, M Lotfaliany, A Turner, OM Dean, SM Cotton, C Diaz-Byrd, AK Yocum, ER Duval, TJ Ehrlich, DF Marshall, M Berk, MG McInnis

2022-06-01

Background: Childhood trauma is associated with greater depression severity among individuals with bipolar disorder. However, the ..

Childhood trauma and treatment outcomes during mood-stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder

AL Wrobel, O Köhler-Forsberg, LG Sylvia, SE Russell, OM Dean, SM Cotton, M Thase, JR Calabrese, T Deckersbach, M Tohen, CL Bowden, MG McInnis, JH Kocsis, ES Friedman, TA Ketter, RC Shelton, MJ Ostacher, DV Iosifescu, M Berk, A Turner

2022-06-01

Background: Childhood trauma affects the course of mood disorders. Researchers are now considering childhood trauma as an influent..

Quality of life in first episode psychosis: a cluster analytic approach

Z Liao, K Allott, JFI Anderson, E Killackey, SM Cotton

2022-06-01

Purpose: Quality of life is increasingly recognised as an important outcome for young people with first episode psychosis (FEP). T..

The Role of Instrumental Swallowing Assessment in Adults in Residential Aged Care Homes: A National Modified Delphi Survey Examining Beliefs and Practices

O Birchall, M Bennett, N Lawson, SM Cotton, AP Vogel

2022-06-01

Many adults in residential aged care homes (RACHs) live with oropharyngeal dysphagia (OD) and its physiological, psychosocial, and..

Severe and complex youth depression: Clinical and historical features of young people attending a tertiary mood disorders clinic

SM Rice, B McKechnie, S Cotton, A Brooker, V Pilkington, B Youzchalveen, L Schmaal, CG Davey

2022-03-01

Aim: The concept of severe and complex youth depression has evolved from clinical experience. Here we conducted a file audit study..

The specific phenotype of depression in recent onset schizophrenia spectrum disorders: A symptom profile and network comparison to recent onset major depressive disorder without psychotic features

SE Herniman, SJ Wood, SM Cotton, KA Allott, C Davey, M Berk, LJ Phillips, E Liemburg, S Castelein, W Veling, R Bruggeman, H Knegtering

2022-02-01

The specific phenotype of depression in recent-onset schizophrenia spectrum disorders (SSD) and its relation to non-psychotic depr..

The influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: A systematic review and meta-analysis

AL Wrobel, A Jayasinghe, SE Russell, W Marx, L Alameda, OM Dean, SM Cotton, M Berk, A Turner

2022-01-01

Objective: The influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for a..

Validation of a brief tool to assess and monitor suicidal ideation: The Youth Suicide Ideation Screen (YSIS-3)

SE Hetrick, CX Gao, KM Filia, JM Menssink, DJ Rickwood, H Herrman, I Hickie, P McGorry, N Telford, AG Parker, SM Cotton

2021-12-01

Background:. Suicidal ideation is common in young people. Assessment and monitoring can help to understand its dynamic nature and ..

The psychometric characteristics of the Kessler Psychological Distress Scale (K6) in help-seeking youth: What do you miss when using it as an outcome measure?

SM Cotton, J Menssink, K Filia, D Rickwood, IB Hickie, M Hamilton, S Hetrick, A Parker, H Herrman, PD McGorry, C Gao

2021-11-01

This is the first study to describe psychometric properties of the Kessler Psychological Distress Scale (K6) in a large cohort of ..

Interrelationships between depressive symptoms and positive and negative symptoms of recent onset schizophrenia spectrum disorders: A network analytical approach

SE Herniman, LJ Phillips, SJ Wood, SM Cotton, EJ Liemburg, KA Allott

2021-08-01

Objective: There is a need to better understand the interrelationships between positive and negative symptoms of recent-onset schi..

Characteristics and predictors of suicidality in young people with clinical depression: A systematic review protocol

CI Moller, CG Davey, PB Badcock, SM Cotton

2021-05-07

Objective:The objective of this review is to examine clinical, psychosocial, and biological factors associated with suicidality in..

Trajectories of change in depression symptoms and suicidal ideation over the course of evidence-based treatment for depression: Secondary analysis of a randomised controlled trial of cognitive behavioural therapy plus fluoxetine in young people

K Witt, T Madsen, M Berk, O Dean, A Chanen, PD McGorry, S Cotton, CG Davey, S Hetrick

2021-05-01

Objectives: Effective treatment of depression is a key target for suicide prevention strategies. However, only around one-third of..

Influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: Protocol for a systematic review and meta-analysis

A Wrobel, SE Russell, OM Dean, S Cotton, M Berk, A Turner

2021-04-29

Despite available pharmacological and psychological treatments, remission rates for bipolar disorder remain relatively low. Curren..

Relationships Between Different Dimensions of Social Support and Suicidal Ideation in Young People with Major Depressive Disorder

CI Moller, SM Cotton, PB Badcock, SE Hetrick, M Berk, OM Dean, AM Chanen, CG Davey

2021-02-15

Background: Suicidal ideation (SI) is a common feature of depression and is closely associated with suicidal behaviour. Social sup..

Instrumental Swallowing Assessment in Adults in Residential Aged Care Homes: A Scoping Review

O Birchall, M Bennett, N Lawson, SM Cotton, AP Vogel

2021-02-01

Objectives: To systematically describe evidence on the use of instrumental swallowing assessment for residents of aged care homes...

The psychometric validity of the Montgomery–Åsberg Depression Rating Scale (MADRS) in recent onset schizophrenia spectrum disorders

SE Herniman, SM Cotton, KA Allott, LJ Phillips, SJ Wood, E Liemburg, S Castelein, W Veling, R Bruggeman, H Knegtering

2021-02-01

Earlier recognition and accurate assessment of depressive symptoms is important to improving outcomes in individuals with recent-o..

Rates, types and associations of sexual risk behaviours and sexually transmitted infections in those with severe mental illness: a scoping review

M Stevens, A Ratheesh, A Watson, K Filia, BO Donoghue, SM Cotton

2020-08-01

The aim of this scoping review was to: (i) determine rates and types of sexual risk behaviours and sexually-transmitted infections..

Diet quality, dietary inflammatory index and body mass index as predictors of response to adjunctive N-acetylcysteine and mitochondrial agents in adults with bipolar disorder: A sub-study of a randomised placebo-controlled trial

MM Ashton, OM Dean, W Marx, M Mohebbi, M Berk, GS Malhi, CH Ng, SM Cotton, S Dodd, J Sarris, M Hopwood, K Faye-Chauhan, Y Kim, SR Dash, FN Jacka, N Shivappa, JR Hebert, A Turner

2020-02-01

Aims: We aimed to explore the relationships between diet quality, dietary inflammatory potential or body mass index and outcomes o..

Aripiprazole compared with placebo for auditory verbal hallucinations in youth with borderline personality disorder: Protocol for the VERBATIM randomized controlled trial

AM Chanen, J Betts, H Jackson, P McGorry, B Nelson, SM Cotton, C Bartholomeusz, M Jovev, A Ratheesh, C Davey, C Pantelis, L McCutcheon, S Francey, A Bhaduri, D Lowe, V Rayner, K Thompson

2019-12-01

Aim: Up to half of patients with borderline personality disorder report auditory verbal hallucinations that are phenomenologically..

Improving functional outcomes in early-stage bipolar disorder: The protocol for the REsearch into COgnitive and behavioural VERsatility trial

SM Cotton, M Berk, H Jackson, G Murray, K Filia, M Hasty, A Chanen, C Davey, B Nelson, A Ratheesh, C MacNeil

2019-12-01

Aim: Young people with bipolar disorder (BD) commonly experience reduced quality of life, persistent symptoms and impaired functio..

Sleep problems and anxiety from 2 to 8 years and the influence of autistic traits: a longitudinal study

J Uren, AL Richdale, SM Cotton, AJO Whitehouse

2019-08-01

Whether or not childhood sleep problems and anxiety occur simultaneously, or one precedes the other, and any effect of autistic tr..

Protocol and rationale: A 24-week double-blind, randomized, placebo controlled trial of the efficacy of adjunctive garcinia mangostana linn. (Mangosteen) pericarp for schizophrenia

A Turner, JJ McGrath, OM Dean, S Dodd, A Baker, SM Cotton, JG Scott, BE Kavanagh, MM Ashton, AJ Walker, E Brown, M Berk

2019-05-01

Objective: Garcinia mangostana Linn., commonly known as mangosteen, is a tropical fruit with a thick pericarp rind containing bioa..

HORYZONS trial: Protocol for a randomised controlled trial of a moderated online social therapy to maintain treatment effects from first-episode psychosis services

M Alvarez-Jimenez, S Bendall, P Koval, S Rice, D Cagliarini, L Valentine, S D'Alfonso, C Miles, P Russon, DL Penn, J Phillips, R Lederman, G Wadley, E Killackey, O Santesteban-Echarri, C Mihalopoulos, H Herrman, C Gonzalez-Blanch, T Gilbertson, S Lal

2019-02-01

Introduction Specialised early intervention services have demonstrated improved outcomes in first-episode psychosis (FEP); however..